Read article at publisher's site (DOI): 10.1080/080352500750027510. the sTfR/log ferritin index (sTfR Index) from these two measures provides an estimate of body iron over a wide range of normal and depleted iron stores [11,15]. Adolescence is a period of increased iron requirements, which impact on iron status. However, a recent meta-analysis demonstrated the greater clinical value of sTfR rather than Soluble Transferrin Receptor (sTfR), Ferritin, and sTfR ... PDF AccuDiag™ (sTfR) Soluble Transferrin Receptor ELISA Use of all three parameters in combination more than doubled the detection of IDA, from 41% (ferritin alone) to 92% (ferritin, sTfR, sTfR Index). Am J Hematol 86:923-927. (sTfR) and the ratio of sTfR/log ferritin (TfR-F index) as a new promising indicator that can differentiate IDA with others especially anaemia of chronic disease (ACD). Serum levels of ferritin, transferrin saturation and sTfR were analyzed in all patients and controls. Two hematological markers give information about the The sTfR Index was superior to sTfR (AUC 0.87 vs. 0.74, P < 0.0001). The sTfR Index thus takes advantage of the reciprocal relationship between two variables influenced by iron deficiency, an increase in sTfR and a decrease in the ferritin concentra-tion. As well as helping identify iron deficiency, sTfR is useful for Ferritin, soluble Transferrin Receptor (sTfR), sTfR/Log ferritin ratio (sTfR-F index), iron, full blood count and high-sensitivity C-reactive protein (hs-CRP) were determined in 110 female . A diagnostic difficulty in RA is the distinction between iron deficiency anaemia (IDA) and ACD. Dessen Bestimmung ist dann sinnvoll, wenn der Ferritinwert nicht aussagekräftig ist. Hematological indices of hypochromia indicate impaired hemoglobin synthesis due to restricted iron delivery to erythrocyte precursors. The purpose of this research is to determine the reference intervals for serum transferrin receptor (sTfR) and sTfR/log ferritin index (sTfR-F index) in healthy adolescents, and their relation with iron parameters and erythropoiesis. The anaemia in RA may be due to anaemia of chronic Three sTfR index studies were, however, eliminated as outliers. The intra- and inter-assay CVs% were 1.5 and 3.3%, respectively. Serum ferritin alone The sTfR/log ferritin index (TfR/logF) was also used. However, whether they could be useful in evaluating the . 2015;45(4):396-402. Acknowledgments Furthermore, because serum ferritin reflects the storage iron compartment and sTfR reflects the functional iron compartment, the sTfR/log ferritin index has been suggested as a good estimate of total body iron (Kotisaari et al., 2003). While ferritin measurement is the accepted method for assessment of iron deficiency, ferritin is an acute-phase reactant and elevates in response to processes that do not correlate with iron status, including inflammation, chronic disease, malignancy, and infection. In order to improve the diagnostic accuracy of ferritin or sTfR as a stand-alone marker, the normal cut-off value needed to be increased by 810% and 83% respectively. This is an easy-to-use automated chemiluminescence immunoassay, amenable to routine use in hospitals. The sTfR/log ferritin index has a better diagnostic utility than sTfR for detection iron deficiency anemia in children with IBD. There is a growing amount of literature concerning the role of the sTfR/ferritin or sTfR/log ferritin ratio (sTfR-F index) in the evaluation of anemia in patients with chronic inflammatory diseases, especially diagnosing IDA in the setting of chronic inflammation or discriminating iron deficiency in the absence of anemia [11,13]. Ann Hematol (2009) 88:913-915 DOI 10.1007/s00277-008-0668-4 LETTER TO THE EDITOR Soluble transferrin receptor-ferritin index and estimated body iron in iron-deficiency anemia in "select" chronic diseases Geon Park & Chi Young Park & Sook Jin Jang & Dae Soo Moon & Sang Muk Park & Young Jin Park Received: 30 May 2008 /Accepted: 6 December 2008 / Published online: 10 January 2009 Springer . The combination of these new markers offers an alternative definition of ID with suitable discriminatory power. The ratio of sTfR and log of ferritin (ferritin index) is also very effective in diagnosing IDA (index greater than 2) or differentiating IDA from anemia of chronic diseases (31)(32) (33 . Receiver operating characteristic (ROC) curves were calculated for hepcidin concentration as a test of iron deficiency as compared with surrogate gold standards: serum ferritin less than 15 ng/mL and sTfR/log(ferritin) ratio (sTfR-F index) greater than 3.2 if the CRP was less than 10 mg/L and greater than 2.2 if the CRP was greater than 10 mg/L . The use of serum transferrin receptor (sTfR) measurements and the sTfR-log ferritin index (TfR-F index) in the distinction between ACD and IDA has been proposed. Although several studies have proved the superiority . A Dutch study has found that about 60% of patients with rheumatoid arthritis are anaemic 1, 2. Because SF reflects storage iron and sTfR reflects functional iron, the sTfR/log ferritin index (sTfR-F index), based on these two values, can be calculated and has been shown to be a more . the sTfR/log ferritin index (sTfR-F index), based on these two values, has been suggested as a good estimate of body iron compared with the sTfR/ferritin ratio. Serum ferritin levels reflect iron stores while sTfR levels reflect the degree of availability of iron for cells. Reference values of serum transferrin receptor (sTfR) and sTfR/log ferritin index in healthy children. Use of sTfR and the sTfR Index improves detection of IDA, particularly in situations where routine markers provide equivocal results. TfR-F index was calculated as (sTfR÷log ferritin) in which log refers to "base-10 log." A low TfR-F index <1 indicates anemia of inflammation without iron deficiency, whereas a TfR-F index of >2 reflects true iron deficiency.6Patients with vitamin B12 deficiency, myelodysplasia, or hemolysis were excluded from TfR-F index analysis.16 Vázquez-López MA, López-Ruzafa E, Lendinez-Molinos F, Ortiz-Pérez M, Ruiz-Tudela L, Martín-González M. Pediatr Hematol Oncol, 33(2):109-120, 07 Mar 2016 Cited by: 5 articles | PMID: 26950203 The meta-analysis included 18 sTfR and 10 sTfR index studies. Full text links . the stfr/log ferritin ratio (tfr-f index) has been shown to distinguish between iron-replete and iron-deplete anemic patients effectively, yet its value in diagnosing nonanemic id remains to be verified. The parallel determination of ferritin / sTfR-ferritin index and sTfR / sTfR-ferritin index for diabetes according to CRP would allow to develop additional criteria for the evaluation of iron homeostasis in diabetes. 1997; Thomas and Thomas 2002). Ferritin, als Akut-Phase-Protein, ist bei Entzündungen normal oder erhöht. receptor, sTfR/log ferritin index INTRODUCTION Anaemia is a common extra-articular manifestation of rheumatoid arthritis (RA). The sTfR/log 10 ferritin index (sTfR/logFerr) is directly proportional to the measurement of the functional and storage iron compartments and seems to fully assess body iron status. The sTfR/log ferritin index (TfR/logF) was also used. We calculated the ratio of sTfR to log ferritin (sTfR-F index) and used the cutoff of 1.5 to assess marrow iron depletion (Punnonen et al. Our results show that transferrin saturation remained stable without significant changes throughout the study . What is Known: • In adults, reticulocyte haemoglobin content (CHr), serum transferrin receptor (sTfR) and sTfR/log ferritin index (sTfR-F index) have been evaluated and recognised as reliable indicators of iron deficiency (ID). Prior to the therapy, Hgb and MCV were 118 ± 15.5 g/L and 79 ± 7.7 fl in the infliximab group, and 113 ± 12.5 g/L and 78 ± 5.8 fl in the etanercept group, respectively. Soluble transferrin receptor and its index were not correlated with disease activity or inflammatory markers. Utility of access soluble transferrin receptor (stfr) and stfr/log ferritin index in diagnosing iron deficiency anemia. Mean cell haemoglobin concentration may be an acceptable alternative screening test in resource-poor settings. Shin DH., Kim HS., Park MJ., et al. Ferritin Index (sTfR/log Ferritin) Elevated . sTfR/Log ferritin ratio, i.e. the sTfR index, theoretically taking advantage of the reciprocal relationship between the two variables influenced by iron deficiency (increase of sTfR and decrease of ferritin concentrations) (9&10). Key words: sTfR, ferritin, sTfR/log ferritin, diabetes, CRP INTRODUCTION Iron plays a significant role in the development RESULTS:Forty two IBD patients (41% of UC and 42.9 % of CD) fulfilled the WHO criteria for the diagnosis of anemia. sTfR is a monomer glycoprotein that detached However, whether they could be useful in evaluating the . Especially the sTfR/ferritin or sTfR/log ferritin ratio (sTfR-F index) is gaining an increasing value in the evaluation of anemia for diagnosing IDA in the setting of chronic inflammation or discriminating iron deficiency in the absence of anemia. The sTfR/log ferritin index was determined for all replicates with sTfR and Ferritin values. An index value greater than 1.5 was diagnosed as iron deficiency [5, 19, 20, 22]. STfLF-Index, STfR, serum ferritin levels and red cell indices revealed that 130/210 (61.9%), 160/210(76.2%), 7/210 (3.3%) and 112/210 (53.3%) respectively had iron deficiency. Transferrin-ferritin index is probably the most useful and robust iron marker that best predicts bone marrow iron status. The purpose of this research is to determine the reference intervals for serum transferrin receptor (sTfR) and sTfR/log ferritin index (sTfR-F index) in healthy adolescents, and their relation with iron parameters a … Adolescence is a period of increased iron requirements, which impact on iron status. Here we conducted a meta-analysis of the literature to evaluate the diagnostic efficacy of sTfR and sTfR/log ferritin index. The interpretation of both sTfR and sTfR/log ferritin index is useful in the evaluation of iron status and erythropoietic activity, especially in children with heterozygous beta-thalassemia, infection and malignancies. The specificity significantly improved when the sTfR-ferritin index was used . Therefore, sTfR/log ferritin could provide added value in the routine diagnostic anemia work-up in children with IBD particularly in those with active phase of the disease. Precision results for the Ferritin assay and sTfR/log ferritin assay are shown below Therefore, sTfR/log ferritin could provide added value in the routine diagnostic anemia work-up in children with IBD particularly in those with active phase of the disease. TfR-F index (sTfR/log ferritin) was found 97.72 ± 108.81 in the IDEA group, 52.16 ± 66.25 in the AI group, and 24.36 ± 43.00 in the CD group (p< 0.001). Since routine screening of iron deficiency by bone marrow examination is not feasible for the community-residing, fully ambulatory older . A meta-analysis Determination of serum soluble transferrin receptor (sTfR) is proposed to distinguish between iron-deficiency anemia and anemia of chronic disease. Use of all three parameters in combination more than doubled the detection of IDA, from 41% (ferritin alone) to 92% (ferritin, sTfR, sTfR Index). 1- 3 Although several papers discuss various sources of variability in iron status indices, such as ferritin or sTfR alone, 1, 4- 8 no such data have . Results: The mean levels of ferritin and sTfR were 10.2 ± 8.12 and 22.2 ± 7.96 ng/ml, respectively, and the mean sTfR/log ferritin ratio was 29.3 ± 17.65 nmol/L. Der Ferritin-Index, ein Quotient aus löslichem Transferrinrezeptor (sTfR)/ log Ferritin, ist ein Maß für die Speichereisenreserve. Distinguishing between IDA and ACD is a key step for determining whether iron supplementation would be beneficial.1,2 Soluble transferrin receptor (sTfR) is an alternative parameter to overcome this issue, whereas ferritin play a part in the inflammation process. A total of 902 children with normal iron status, aged 1-11 years, were . Soluble transferrin receptor levels and soluble transferrin receptor/log ferritin index in the . Ferritin, TIBC, and hepcidin showed the highest correlation with CRP, whereas sTfR displayed the lowest. The mean age of the patients is 58.6 ± 14.7 years and . Dr Mohan Z Mani "Thank you very much for having published my article in record time.I would like to compliment you and your entire staff for your promptness, courtesy, and willingness to be customer friendly, which is quite unusual.I was given your reference by a colleague in pathology,and was able to directly phone your editorial office for . iron compartment, the sTfR/log ferritin index (sTfR-F-index), based on these two values, and has been suggested as a good estimate of body iron compared with the sTfR/ferrin ratio. Based on microcytosis, hypochromia, and high sTfR/log serum ferritin index, the prevalence of iron deficiency of 7% obtained in this study is much lower than what was obtained by other authors who reported deficiency in 20% and 17.1% of SCD patients using the combination of microcytosis and hypochromia alone . sTfR is not an acute-phase reactant and the interpretation of iron status using . The soluble transferrin receptor (sTfR), especially in the form of the ratio to the log concentration of ferritin (sTfR/logFerr), has been widely used as a measure of latent iron deficiency. Diagnostic power for soluble transferrin receptor/log ferritin index (0.864) was superior to soluble transferrin receptor (0.768) in iron deficiency anemia recognition. TfR-F index values of the chronic disease anemia group (ACD) and the iron deficiency anemia group accompanied by chronic disease (COMBI) were compared. evaluate the diagnostic efficacy of sTfR and sTfR/log ferritin index. ferritin and the ratio sTfR/log Ferritin (sTfR-Ferritin Index) in the diagnosis of ACD in patients with diabetes referred to control group. The odds ratio was significant for both sTfR (22.9, 95% confidence interval [CI], 9.6-55.0) and sTfR index (9.5, 95% CI, 5.0-18.1) Distinguishing between IDA and ACD is a key step for determining whether iron supplementation would be beneficial. Within run precision for the sTfR /log ferritin index (index range 6.19 to 69.27) was less than 3% CV and the Total precision observed was less than 6%CV. Soluble transferrin receptor (sTfR) and sTfR/log ferritin index for the diagnosis of iron-deficiency anemia. sTfR-log ferritin index. Calculating the sTfR/log ferritin index (sTfR Index) from these two measures provides an estimate of body iron over a wide range of normal and depleted iron stores [ 11, 15 ]. RESULTS:Correlation of ferritin to iron level was changed when its correlation adjusted by confounding inflammation (CRP level > 10). the sTfR/log ferritin index (sTfR-F index), based on these two values, and has been suggested as a good estimate of body iron compared with the sTfR/ferritin ratio. A total of 1239 healthy children . normal CRP. Similar results were found in the case of hemoglobin levels, where The aim of our study was to evaluate the usefulness of serum soluble transferrin receptor (sTfR) and sTfR/log ferritin (TfR-F) index . sTfR-F index was calculated based on the ratio: sTfR/ log ferritin. These two markers not entirely influenced by concurrent chronic disease as well as inflammation [4], [10], [11], [12]. Distinguishing between IDA and ACD is a key step for determining whether iron supplementation would be beneficial. The meta-analysis included 18 sTfR and 10 sTfR index studies. Index of sTfR/log ferritin shows insignificant differences in the placebo group, with highly significant differences (P < 0.002 level) in glucan-supplemented group (Table 1, figure 1). Soluble transferrin receptor (sTfR) and sTfR/log ferritin index for the diagnosis of iron-deficiency anemia. 16 in the present study, the supplementation-induced change was made most apparent by using the tfr-f index, indicating that the nonanemic … The sTfR Index was superior to sTfR (AUC 0.87 vs. 0.74, P < 0.0001). We would like to show you a description here but the site won't allow us. IDA was diagnosed based on TS < 20% and ferritin level < 200 ng/L and functional iron deficiency when TS < 20% and ferritin > 200 ng/L. This cross-sectional study, conducted on a population-based representative sample, evaluates the usefulness of reticulocyte haemoglobin content (CHr), serum transferrin receptor (sTfR) and sTfR/log ferritin (sTfR-F index) to recognise iron deficiency (ID) without anaemia, provides specific cut-off points for age and gender, and proposes a new definition of ID. The Access sTfR and sTfR/log ferritin index enabled highly accurate diagnosis of IDA in the ferritin grey zone. To make the test more specific, the application of the ratio of sTfR to the log ferritin level (sTfR-F index) was suggested. Ferritin, als Akut-Phase-Protein, ist bei Entzündungen normal oder erhöht. Nagral et al, in a study of 51 patients with CLD, showed that the sTfR test is a reliable indicator of ID, provided that hemolysis and recent blood loss have been excluded (sensitivity 91.6%, specificity 84.6%) . Furthermore, because serum ferritin reflects the storage iron compartment and sTfR reflects the functional iron compartment, the sTfR/log ferritin index (sTfR-F index), based on these two values, has been suggested as a good estimate of body iron compared with the sTfR/ferritin ratio . The anaemia in RA may be due to anaemia of chronic The iron status and inflammatory status of the body are two independent causes that affect serum ferritin levels ( Northrop-Clewes, 2008 ). A meta-analysis. Am J Clin Pathol, 138:642-9. Hence, the correlation between the sTfR ratio and the sTfR/log ferritin ratio with conventional iron status parameters in regular hemodialysis patients is necessary to be evaluated. Furthermore, because serum ferritin reflects the storage iron compartment and sTfR reflects the functional iron compartment, the sTfR/log ferritin index (sTfR-F index), based on these two values, has been suggested as a good estimate of body iron compared with the sTfR/ferritin ratio . All responders had a significant decrease (P, 0.0001) in sTfR and TfR-F Index values. A meta-análise incluiu 18 sTfR e 10 estudos índice sTfR. employed sTfR/ log ferritin ratio, sTfR-F index as the tool for the diagnosis of iron deficiency anaemia and a cut-off value of >1.85 has been determined.17In another study, the mean index was >1.4, indicating iron deficiency anaemia co-existing with anaemia of chronic disease; however, index up to 1.3 shows merely an anaemia of Determinação de receptores de transferrina solúvel (sTfR) propõe-se distinguir entre a anemia ferropriva e anemia da doença crônica. In chronic inflammation, ferritin as an acute-phase reactant is of no diagnostic value and bone marrow aspirate as gold standard is invasive and its use requires specialised skills. The mean hepcidin levels were 9 . There is a growing amount of literature concerning the role of the sTfR/ferritin or sTfR/log ferritin ratio (sTfR-F index) in the evaluation of anemia in patients with chronic inflammatory diseases, especially diagnosing IDA in the setting of chronic inflammation or discriminating iron deficiency in the absence of anemia [11,13]. Advertisers Access Statistics Resources. The aims of this study were to determine appropriate reference ranges for serum transferrin receptor (sTfR) and sTfR/log ferritin (sTfR-F index) in healthy children and their relationship with iron parameters, erythropoiesis, and other conditions presented by the subject. 1. STfR revealed a significantly higher percentage of students with iron deficiency compared to serum ferritin, STfLF-Index and red cell indices. Very sensitive discriminator between classic and functional ID : Thomas Plot, / Januar 2006 / R. Röddiger (Clinical Trials) p 23 Hematology . Moreover, ratio of the soluble transferrin receptor (sTfR) to log ferritin ratio (sTfR Index) presumably ensure a better prediction of iron status of body (Kell and Pretorius, 2014). The ratio of sTfR concentration to (log) ferritin concentration (the TfR-Index; both variables determined by immunoassay) thus displays an inverse linear relationship to iron status over the full range of iron status from normal iron stores to significant functional iron deficiency. Soluble transferrin receptor/log ferritin (TfR-F index), using a cut-off of 5.6, best predicted bone marrow iron stores deficiency (sensitivity 74%, specificity 73%, accuracy 73%). receptor, sTfR/log ferritin index INTRODUCTION Anaemia is a common extra-articular manifestation of rheumatoid arthritis (RA). Transferrin (reference interval 200-360 mg dl -1) was measured by nephelometry, using a Dade Behring assay. Prior to the therapy, Hgb and MCV were 118 ± 15.5 g/L and 79 ± 7.7 fl in the infliximab group, and 113 ± 12.5 g/L and 78 ± 5.8 fl in the etanercept group, respectively. Eight responders presenting with TfR-F index calculated as sTfR/log ferritin. A Dutch study has found that about 60% of patients with rheumatoid arthritis are anaemic 1, 2. Dessen Bestimmung ist dann sinnvoll, wenn der Ferritinwert nicht aussagekräftig ist. 7. UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Obstetrics, Gynecology, and Women . Dimitriou H, Stiakaki E, Markaki EA, Bolonaki I, Giannakopoulou C, Kalmanti M (2000). Use of sTfR and the sTfR Index improves detection of IDA, particularly in situations where routine markers provide equivocal results. Der Ferritin-Index, ein Quotient aus löslichem Transferrinrezeptor (sTfR)/ log Ferritin, ist ein Maß für die Speichereisenreserve. Skikne BS, Punnonen K, Caldron PH, Bennett MT, Rehu M, Gasior GH, Chamberlin JS, Sullivan LA, Bray KR, Southwick PC (2011) Improved differential diagnosis of anemia of chronic disease and iron deficiency anemia: a prospective multicenter evaluation of soluble transferrin receptor and the sTfR/log ferritin index. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Anaemia of chronic disease (ACD) is a frequent complication of rheumatoid arthritis (RA). METHODS The study involved 81 patients with diabetes from the Clinic of Endocrinology, Medical University-Plovdiv and 41 healty controls. The soluble transferrin receptor (sTfR) test is primarily ordered to help distinguish between anemia that is caused by iron deficiency and anemia that is caused by inflammation or a chronic illness (so-called anemia of chronic disease or inflammation). Determination of serum soluble transferrin receptor (sTfR) is proposed to distinguish between iron-deficiency anemia and anemia of chronic disease. 1,2. sTfR AND TfR-F INDEX AND IRON DEFICIENCY IN RA 1017. patients (11 of 12 with BMI 0 and 4 of 6 with BMI 1/11) exhibited a positive response. The value of sTfR and sTfR-F for diagnosis of IDA was assessed. The sTfR/log ferritin index has a better diagnostic utility than sTfR for detection iron deficiency anemia in children with IBD. Aqui nós conduziram uma meta-análise da literatura para avaliar a eficácia diagnóstica de sTfR e sTfR / log índice de ferritina. 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