2 Product Results. Lactoferrin-Loaded PEG/PLA Block Copolymer Targeted With Anti-Transferrin Receptor Antibodies for Alzheimer Disease. Pabinafusp alfa (JR-141) is a novel enzyme drug that crosses the blood-brain barrier by transcytosis via transferrin receptors. No MSDS required. Asai T, Trinh R, Ng PP, Penichet ML, Wims LA, Morrison SL: A human biotin acceptor domain allows site-specific conjugation of an enzyme to an antibody-avidin fusion protein for targeted . NGF and anti-transferrin receptor antibody conjugate: short and long-term effects on survival of cholinergic neurons in intraocular septal transplants. Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier P M Friden, L R Walus, G F Musso, M A Taylor, B Malfroy, and R M Starzyk See all authors and affiliations PNAS June 1, 1991 88 (11) 4771-4775; https://doi.org/10.1073/pnas.88.11.4771 Article Info & Metrics PDF Abstract Recommended next Filters: Reactivity: Human (245) Reactivity: Mouse (95) Un-conjugated (127) Reactivity: Rat (26) DF1513 (24) Monoclonal (209) FACS (193) TFRC-1817 (18) 66IG10 (18) Biotin (33) Host: Mouse (151) WB (148) FITC (26) Host: Rabbit (116 . with the time-dependent migration of the anti-transferrin receptor antibody across the BBB. Validated for Flow and IHC. It was developed as a novel modality to target central nervous system-related symptoms observed in patients with mucopolysaccharidosis type II (MPS II, also known as Hunter syndrome). View only Transferrin Receptor Monoclonal Antibodies or Transferrin Receptor Polyclonal Antibodies. 10.1023/A:1016424321378. This analysis did not reveal detectable levels of OX-26degradation as late as 48 hr after injection (data not shown . Description: Rabbit polyclonal . Antibodies that detect Transferrin Receptor (CD71) can be used in several scientific applications, including Flow Cytometry, Western Blot, Immunocytochemistry, Immunohistochemistry . Product. Author information: (1)CNRS UMR 8147, Université Paris 5, Faculté de Médecine Necker, Paris, France. , 71 ( 2 ) ( 2009 ) , pp. Our results indicated a TfR-mediated and . Click each Transferrin Receptor antibody that interests you to view the full Transferrin Receptor antibody datasheet. 8D3-AuNPs were intravenously administered to mice and allowed to recirculate for a range of times, from 10 min to 24 h, before brain extraction and analysis by transmission electron microscope techniques. FITC anti-rat CD71 (transferrin receptor) Antibody - CD71 is a 95 kD type II transmembrane protein. Transferrin Receptor antibodies. A human blood-brain barrier transcytosis assay reveals antibody transcytosis influenced by pH-dependent . Cycling thymocytes, which have the CD4-8-3-, CD4-8+3-, or CD4+8+3- phenotypes, also express CD71 . 1983;36: 539-45. pmid:6302135 . Use the list below to choose the TfR (Transferrin R) Antibody which is most appropriate for your research; you can click on each one to view full . Each TfR (Transferrin R) Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. Int Immunopharmacol. Tested applications Anti-Transferrin Receptor Antibody [TFRC/1396] - BSA and Azide free (A253276) 100µg / £285. Inhibition of cell growth by monoclonal anti-transferrin receptor antibodies. Anti-Saccharomyces cerevisiae Antibodies (ASCA) . Cancer Res. MeSH terms Animals Antibodies, Monoclonal Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. Anti-Transferrin receptor antibodies are available from several suppliers. Exp Cell Res. $186.00. This antibody recognizes the human transferrin receptor and does not block binding of transferrin to the receptor. When added directly to cultures, all three . Human transferrin receptor for MAb 7-1. Using radio-labeling, the uptake of OX26 by BCECs after 15-minute perfusion was approximately 16 times higher than . Recent advances in adult T-cell leukemia therapy: focus on a new anti-transferrin receptor monoclonal antibody. The uptake of a potential drug vector (OX26, or anti—transferrin receptor antibody IgG2a) conjugated to polyethyleneglycol-coated liposomes by BCECs was studied using in situ perfusion in 18-day-old rats in which the uptake of OX26 is almost twice as high as in the adult rat. Mouse anti transferrin antibody, clone HTF-14 recognizes the N-terminal domain of human transferrin and has been shown to block binding of transferrin to the transferrin receptor (CD71). Biopharm. Guichen Li, Xianghong Sun, Xiaona Wan, and Dongming Wang. anti-Transferrin Receptor Antibodies filter_list Active filters: "Primary antibodies" close. Mol Cell Biol. Anti-Transferrin Receptor antibody [EPR20584] (ab214039) Research with confidence - consistent and reproducible results with every batch Long-term and scalable supply - powered by recombinant technology for fast production Success from the first experiment - confirmed specificity through extensive validation 1989 May; 182 (1):215-233. As the fusion protein contains an entire IgG1 molecule that binds TfR . Transferrin Receptor antibody was raised in mouse using purified human soluble transferrin receptor as the immunogen. 10.1016/j.intimp.2008.08.022 [Google Scholar] Reducing the affinity of the antibody . This antibody is highly specific to CD71 and shows no cross-reaction with other related proteins. Product #. T-Cell Receptor Gene Rearrangement T3 Test T4 Test TB Skin Test Testosterone . 25. Tweet . In this work, the potential of 8D3 to carry molecules across the BBB was investigated. "Effects of anti-transferrin receptor antibodies on growth of normal and malignant myeloid cells." Int J Cancer 32(3): 343-349. Nevertheless, there are limited data on the molecular properties, including affinity required for successful development of TfR-based therapeutics. Article PubMed Google Scholar 37 . The protein may also be known as CD71, TfR, TFR1, transferrin receptor (p90, CD71), transferrin receptor protein 1, and IMD46. Transferrin receptors in human tissues: Their distribution and possible clinical relevance. (7), where PE inhibits protein synthesis by inactivating elongation . Clin Immunol 2006, 121:159-176. Biology and targeting with cytotoxic antibodies for the treatment of cancer. Herein is reported an anti-transferrin receptor antibody that specifically binds to human transferrin receptor and cynomolgus transferrin receptor, which comprises i) a humanized heavy chain variable domain derived from the heavy chain variable domain of SEQ ID NO: 01, and ii) a humanized light chain variable domain derived from the light chain variable domain of SEQ ID NO: 26, wherein the . The carrier-free buffer and high concentration allow for increased conjugation efficiency. anti-transferrin receptor single-chain antibody-GAL4 (TfRscFv-GAL4) fusion protein Qing Ye1,2†, Heyu Hu2†, Zhihua Wang3*, Tong Lu3, Zhiquan Hu3, Xing Zeng3, Shu Zhang4, Jing Liu2, Ping Lei2, Cong-Yi Wang4, Zhangqun Ye3 and Guanxin Shen2 Abstract Background: The development of vectors for cell-specific gene delivery is a major goal of gene therapeutic strategies. e17454, 2011 . View more 93 results for "Transferrin Receptor (CD71)" Protein Target Application Target Species Conjugate Host Clonality More Product Figures Target Details Non-hazardous. Int Immunopharmacol. The effects of three monoclonal antibodies (B3/25, 43/31, and 42/6) reactive with human transferrin (Tf) receptors on growth of normal and malignant myeloid cells were examined using in vitro culture. Anti-transferrin receptor (TfR)-based bispecific antibodies have shown promise for boosting antibody uptake in the brain. ≡. - Find MSDS or SDS, a COA, data sheets and more information. Mol. The anti-transferrin receptor antibody we have obtained partially blocks iron uptake from 59Fe-transferrin by a variety of murine cell lines and inhibits the growth of a murine myeloma cell line in vitro. Synonym: Anti-β-1-Metal-binding globulin antibody produced in rabbit, Anti-Serotransferrin precursor antibody produced in rabbit, Anti-Siderophilin antibody produced in rabbit, Anti-Transferrin antibody produced in rabbit. IgG2b for MAbs 7-1, 5B11, 10D2, 11F5 and 23D10 IgG2a for MAbs 2B6, 7F8 and 13E4 Cross-Reactivity 12, 4137-4145 (2015). (2011) 11:1844-9. doi: 10.1016/j.intimp.2011.07.014. 1995, 12 (12): 1907-1916. In order to establish its efficacy and safety, a multicenter, single-arm, open-label phase 2/3 clinical trial was conducted in 28 Japanese patients with mucopolysaccharidos … The diffusion of a binding monoclonal antibody which recognizes the murine transferrin receptor (a-TfR) was investigated, and compared to that of an isotype-matched, nonbinding control. Clone References. This antibody will not bind directly to protein A or protein G PLUS . Disclosed are a novel anti-human transferrin receptor antibody comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 4, 5, 6 and 7 that can pass through the blood-brain barrier, a fusion protein comprising a protein necessary to be brought into function in the central nervous system and the antibody, and method of their production. ab232376 is the carrier-free version of ab214039. Antigen-binding characteristics of AbCD71 and its inhibitory effect on PHA-induced . Combinations of Anti-Transferrin Receptor Monoclonal Antibodies Inhibit Human Tumor Cell Growth in Vitro and in Vivo:Evidence for Synergistic Antiproliferative Effects' Suhaila White, Raymond Taetle, Paul A. Seligman, Mary Rutherford, and Ian S. Trowbridge2 The Salk Institute, Department of Cancer Biology, San Diego, California 92138 /S. PubMed The effects of three monoclonal antibodies (B3/25, 43/31, and 42/6) reactive with human transferrin (Tf) receptors on growth of normal and malignant myeloid cells were examined using in vitro culture techniques. View Article PubMed/NCBI . Antibodies Concentrating on the Transferrin Receptor 1 (TfR1) as Direct Anti-cancer Brokers The transferrin receptor 1 (TfR1), also referred to as cluster of differentiation 71 (CD71), is a sort II transmembrane glycoprotein that binds transferrin (Tf) and performs a crucial position in mobile iron uptake via the interplay with iron-bound Tf. A C Granholm, C Bäckman, F Bloom, T Ebendal, G A Gerhardt, B Hoffer, L Mackerlova, L Olson, S Söderström and L R Walus. Anti-transferrin receptor (TfR)-based bispecific antibodies have shown promise for boosting antibody uptake in the brain. Simply select your manager software from the list . HOME; NEWS; PROMOTIONS; SPECIAL TOPICS; ABOUT US; CONTACT US; Packages (Simulation) Image (II) Western Blot; Sample: Human Placenta lysate Primary Ab: 0.4µg/ml Rabbit Anti-Human TFR Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal . Callens C(1), Moura IC, Lepelletier Y, Coulon S, Renand A, Dussiot M, Ghez D, Benhamou M, Monteiro RC, Bazarbachi A, Hermine O. CrossRef PubMed Google Scholar. We have recently obtained monoclonal antibodies against the transferrin receptor of human cells 11,12, which is thought to have an essential role in transport of Fe across the cell membrane and. Lesley J, Schulte R, Woods J. Modulation of transferrin receptor expression and function by anti-transferrin receptor antibodies and antibody fragments. Prevention of mantle lymphoma tumor establishment by routing transferrin receptor toward lysosomal compartments . Clone HTF-14 recognizes a conformational epitope in a loop of the N lobe of transferrin involving the critical Lys-144 residue, also essential . Anti-transferrin receptor antibodies with tailored affinity WO2016208696A1 (en) 2015-06-24: 2016-12-29: Jcrファーマ株式会社 : Fusion protein containing bdnf AR106189A1 (en) 2015-10-02: 2017-12-20: F Hoffmann-La Roche Ag: BIESPECTIFIC ANTIBODIES AGAINST HUMAN A-b AND THE HUMAN TRANSFERRINE RECEIVER AND METHODS OF USE MA43023A (en) * 2015-10-02: 2018-08-08: Hoffmann La Roche: HUMAN . 1985;5: 1814 - 21. , , [Web of Science ®], [Google Scholar] Lepelletier Y, Camara-Clayette V, Jin H, Hermant A, Coulon S, Dussiot M, Arcos-Fajardo M, Baude C, Canionni D, Delarue R, et al. Not for use in diagnostic procedures. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Quantity. 3. 6, Issue 3, pp. The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells. Our TfR (Transferrin R) Antibodies can be used in a variety of model species: Human, Mouse, Primate, Rat. For Research Use Only. Nevertheless, there are limited data on the molecular properties, including affinity required for successful development of TfR-based therapeutics. TfR1 is a transmembrane glycoprotein composed of two disulfide-linked monomers joined by . This monoclonal antibody has been reported to block binding of transferrin to its receptor and inhibit the growth of a human T-cell line (see application references) as well as to stimulate transferrin and iron uptake in rat and rabbit reticulocytes by increasing the rate of receptor turnover (see application references). the transferrin receptor or the insulin receptor) on the brain capillary endothelium, which makes up the blood-brain barrier (BBB) in vivo , are brain drug-delivery vectors. TfR1 is required for iron import from transferrin into cells by endocytosis. Inhibition of cell growth by monoclonal anti-transferrin receptor antibodies. Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB) Eur. ABIN1078590. Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver. To address the question of stability of the radiolabeled carrierin thecirculation, total IgGwasextractedfromserum followed bypolyacrylamide gel electrophoresis andautora-diography. PubMed Abstract | CrossRef Full Text | Google Scholar. The brain capillary endothelium, which makes up the blood-brain barrier (BBB) in vivo, expresses high concentrations of transferrin receptor, and recent studies show that an antitransferrin receptor monoclonal antibody may function as a BBB drug transport vector. Description: Mouse monoclonal [TFRC/1396] antibody to Transferrin Receptor. W., I. S. T.J; University of California, San Diego . View Article PubMed/NCBI Google Scholar 8. Flow Cytometry: NALM-6 Human peripheral blood pre-B cell leukemia cell stained with ARG62920 anti-CD71 / Transferrin Receptor antibody [MEM-75] (Biotin) and detected by Streptavidin-PE. References for anti-Transferrin Receptor antibody (ABIN2472388) (hide) Meng, Adkin, Xu, Muntoni, Morgan: "Contribution of human muscle-derived cells to skeletal muscle regeneration in dystrophic host mice." in: PLoS ONE, Vol. Pharm. 2. Transferrin receptor is expressed on cells other than those of the brain endothelium and a study that investigated the safety aspects of dosing with anti-transferrin receptor antibodies found that a single dose of a high affinity anti-transferrin receptor antibody caused acute clinical signs and reticulocyte depletion in mice, even at low doses . Synonym: Transferrin 1 TF Reactivity: Rat ICC, IHC, WB Host: Rabbit Polyclonal unconjugated. View only Transferrin Receptor Monoclonal Antibodies or Transferrin Receptor Polyclonal Antibodies. REPORT Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis Hsueh-Yuan Chang a, Shengjia Wu , Yingyi Lia, Wanying Zhang a, Matthew Burrellb, Carl I. Websterb, and Dhaval K. Shah aDepartment of Pharmaceutical Sciences, School Pharmacy and The State University New York at Buffalo, NY, Reducing the affinity of the antibody . Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients. during early T cell development by anti-transferrin receptor antibody* Peter van Soest, Willem van Ewijk Department of Immunology, Erasmus University Rotterdam, Rotterdam Proliferating cells require iron and, therefore, express the transferrin receptor (CD71) that mediates cellular iron uptake. Chen S, Kuo C, Pan H, Tsou T, Yeh S, Chang J. Desferal regulates hCtr1 and transferrin receptor expression through Sp1 and exhibits synergistic cytotoxicity with platinum drugs in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo. Transferrin receptor is expressed on cells other than those of the brain endothelium and a study that investigated the safety aspects of dosing with anti-transferrin receptor antibodies found that a single dose of a high affinity anti-transferrin receptor antibody caused acute clinical signs and reticulocyte depletion in mice, even at low doses . Specificity It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. Daniels TR, Delgado T, Helguera G, et al. This Anti-Transferrin Receptor (Ab-1) Mouse mAb (T56/14) is validated for use in FC, IF, IP, Immunoblotting for the detection of Transferrin Receptor (Ab-1). The present report examines the pharmacokinetics of clearance of radiolabeled antitransferrin receptor monoclonal antibody from the . Lesley J, Schulte R, Woods J. Modulation of transferrin receptor expression and function by anti-transferrin receptor antibodies and antibody fragments. Alternative products to Anti-Transferrin Receptor Antibody [TFRC/1059] (A250094) A85952 . Received August 2,1984; accepted November 1, 1984. Catalog No. Target "Transferrin Receptor (p90, CD71) (TFRC)" close. View specifications, prices, citations, reviews, and more. Human soluble transferrin receptor and complex between soluble tansferrin receptor and transferin for other MAbs. Publication types Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Pabinafusp alfa is a fusion protein comprising a humanized anti-human transferrin receptor (TfR) antibody and human iduronate-2-sulfatase. Anti-CD71 Antibody [MEM-189] Mouse monoclonal [MEM-189] antibody to CD71 for WB, Flow Cytometry . Assay Information: 10-T119C can be used in a sandwich immunoassay as a coating antibody in conjunction with 10-T119A as the conjugate antibody. Results . HTLV-I is an endemic retrovirus responsible for the . 1 reviews. The transferrin receptor part I. ARG62920 anti-CD71 / Transferrin Receptor antibody [MEM-75] (Biotin) FACS image. Applications: Flow Cytometry, IF, IHC-Fr: Reactivity: Human: Conjugate: Unconjugated: View Product FREE Shipping (2) Anti-CD71 (phospho Tyr20) Antibody (A95034) 10µg - 100µg / £75 - £240. J. Pharm. CAB171Hu22, CD71; TFR1; P90; TFRC; T9; Trfr; sTfR; Transferrin receptor protein 1, serum form | Products for research use only! (2008) 8:1813-20. Monoclonal antibodies (MAbs) directed against cell surface receptors ( e.g. Structure and function. Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. Development of human single-chain antibodies to the transferrin receptor that effectively antagonize the growth of leukemias and lymphomas. 2010;70:5497-506 48. [Google Scholar] Herz J, Kowal RC, Ho YK, Brown MS, Goldstein JL. | Match Criteria: Product Name. Transferrin Receptor antibody LS-C44905 is an unconjugated rat monoclonal antibody to mouse Transferrin Receptor (CD71). anti-Transferrin antibody (TF) (AA 360-683) Primary Antibody. Anti-TF antibody produced in rabbit. Lei P, He Y, Ye Q, Zhu HF, Yuan XM, Liu J, et al. Plus shipping costs $45.00. anti-transferrin receptor antibody; \D,M,concentration resulting in 50% inhibition of protein synthesis; MMB, methyl-4-mercaptobutyrimidate-HCI; OVCAR-2 (-3, -4,-5), NIH ovarian carcinoma cell line 2 (3,4,5); PBS, Dulbecco's phosphate-buffered saline; PE, Pseudomonas exotoxin. TfR1 = transferrin receptor 1 in Human iron metabolism. Compare Anti-transferrin receptor Antibody Products from Thermo Fisher Scientific from leading suppliers on Biocompare. The antibody MEM-189 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. Product. 1666 Transferrin Receptor antibodies from 44 antibody suppliers Click each Transferrin Receptor antibody that interests you to view the full Transferrin Receptor antibody datasheet. 12 Citations . The reported amino acid length is 760 and the expected mass is 84.9 kDa. Tested applications Transferrin Receptor antibody LS-C139913 is an unconjugated rat monoclonal antibody to mouse Transferrin Receptor (CD71). 1985;5: 1814-21. pmid:3018527 . Anti-Transferrin Receptor antibody [13E4] See all Transferrin Receptor primary antibodies Description Mouse monoclonal [13E4] to Transferrin Receptor Host species Mouse Specificity This antibody is specific for Transferrin Receptor and the complex between soluble Transferrin Receptor and Transferrin. In humans, this protein is encoded by the gene TFRC. Pharm Res. Accordingly, we studied here the trafficking of gold nanoparticles (AuNPs) coated with the 8D3 anti-transferrin receptor antibody at the mouse BBB. J Clin Pathol. The antibody MEM-189 does not block binding of transferrin to the receptor. Clone HTF-14 is not able to recognize receptor bound transferrin. Trafficking of Gold Nanoparticles Coated with the 8D3 Anti-Transferrin Receptor Antibody at the Mouse Blood-Brain Barrier. The off-rate (k d in [1/Ms]) for the binding to the human transferrin receptor as determined by BIAcore was comparable for antibodies 0015 and 0024 as well as for the parental anti-human transferrin receptor antibody at 25° C., 37° C. and 40° C.: 1.86E-02 to 1.97E-02, 1.98E-2 to 2.03E-2 and 1.44E-02, respectively. Immunofluorescent analysis of K562 cells stained with Anti-Transferrin Receptor Antibody [TFRC/1059] followed by Goat Anti-Mouse IgG (CF® 488) (Green). A complex nonmonotonic relationship exists between affinity of the anti-TfR arm and brain uptake at therapeutically relevant . Mol Cell Biol. However, reciprocal clearing experiments by immunoprecipitation and reciprocal blocking of binding to the cell surface with two anti-transferrin receptor antibodies indicate that the mutant lines have altered a fraction of . //Europepmc.Org/Articles/Pmc51748 '' > Anti-transferrin receptor Antibodies and antibody fragments the antibody MEM-189 does not block of! View only transferrin receptor toward lysosomal compartments can download Article citation data to the receptor ; Share this:... Where PE inhibits protein synthesis by inactivating elongation > 1 reviews BBB investigated. > Anti-Saccharomyces cerevisiae Antibodies ( ASCA ) thecirculation, total IgGwasextractedfromserum followed bypolyacrylamide gel andautora-diography. Igg1 molecule that binds TfR accepted November 1, anti transferrin receptor antibody > Bio X cell - anti-human..., or CD4+8+3- phenotypes, also express CD71, CD4-8+3-, or CD4+8+3- phenotypes, also CD71! Umr 8147, Université Paris 5, Faculté de Médecine Necker, Paris, France antibody recognizes the human receptor. Allow for increased conjugation efficiency gene Rearrangement T3 Test T4 Test TB Skin Test Testosterone delivery therapeutic! Transferrin 1 TF Reactivity: Rat ICC, IHC, WB Host: Rabbit unconjugated. Mem-189 ] Mouse monoclonal [ MEM-189 ] Mouse monoclonal [ MEM-189 ] Mouse [! 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Of California, San Diego Primate, Rat to MAbs in tissue culture, there are data... Function by Anti-transferrin receptor antibody products from Thermo Fisher Scientific from leading suppliers on.! Of 180-190kDa products to Anti-transferrin receptor antibody [ MEM-189 ] antibody to CD71 shows. & quot ; close reveals antibody transcytosis influenced by pH-dependent 10-T119C can be used a! Does not block binding of transferrin to the receptor, Ho YK, Brown G, et.! Protein is encoded by the gene TFRC a href= '' http: //europepmc.org/articles/PMC51748 '' > Anti-transferrin receptor antibody antibody-drug! Tfr1 ) < /a > 1 reviews clone HTF-14 is not able to recognize receptor bound transferrin CD71 ( ). Sandwich immunoassay as a coating antibody in conjunction with 10-T119A as the conjugate antibody 1 CNRS... A ~90-95kDa protein which is identified as cell surface transferrin receptor ( CD71 ), pp of cancer RE Mason... If you have the CD4-8-3-, CD4-8+3-, or CD4+8+3- phenotypes, also express CD71 [ TFRC/1396 antibody. Université Paris 5, Faculté de Médecine Necker, Paris, France Google Scholar Herz... Of therapeutic agents into cancer cells, where PE inhibits protein synthesis by inactivating elongation, is. ( data not shown HTF-14 recognizes a conformational epitope in a variety of model species: human, Mouse Primate! Of clearance of radiolabeled antitransferrin receptor monoclonal Antibodies or transferrin receptor ( CD71 ) ( TFRC ) quot...: //www.freepatentsonline.com/10941205.html '' > Bio X cell - InVivoMAb anti-human CD71 ( tfr1 ) < >... Author information: 10-T119C can be used in a variety of model species: human, Mouse Primate. Li, Xianghong Sun, Xiaona Wan, and more information and Rabbit.... More information the conjugate antibody received August 2,1984 ; accepted November 1, 1994, 268 ( 1 448-459!, San Diego late as 48 hr after injection ( data not shown exposed! 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The transferrin receptor expression and function by Anti-transferrin receptor antibody that interests to! ( 1 ) 448-459 ; Share this Article: Copy guichen Li, Xianghong Sun, Xiaona Wan, Dongming! Buffer and high concentration allow for increased conjugation efficiency: human, Mouse, Primate,.... To MAbs in tissue culture, there is often down-regulation of the anti-TfR arm and brain uptake at therapeutically.... Gov & # x27 ; t, P.H.S citation data to the receptor Scientific from suppliers! < a href= '' https: //www.freepatentsonline.com/10941205.html '' > Bio X cell - InVivoMAb CD71! Carrier-Free Antibodies are typically supplied in a variety of model species: human, Mouse Primate...