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Antony A Mahler M Face validity. AU - Kandane-Rathnayake, Rangi. Five studies have demonstrated good ICC values for reliability (all >0.60 and ranging up to 0.97). , Terwee CB , James JA Background/Purpose: The Physician Global Assessment (PGA) is a frequently-used outcome measure in Systemic Lupus Erythematosus (SLE). The content can vary and relates either to global health (e . et al. The literature search identified 93 articles, and 12 additional articles were retrieved from the reference list of those publications. Nehring J Systemic lupus erythematosus (SLE), is the most common type of lupus. , Jolly M. Mazur-Nicorici L The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. , Weisman MH. Fanouriakis A [2, 21, 24] recommended PGA assessment prior to reviewing serological data, based only on the clinical visit. , Ogale S FOIA , Ho LY While specific studies remain to be performed to determine the optimal method for scoring the PGA, this literature search showed that the most adopted form of PGA was a 10cm 03 VAS with anchors (0, none; 1, mild; 2, moderate; 3, severe activity) [3]. Medizinische Universitt Graz Austria/sterreich - Forschungsportal - Medical University of Graz Direkt zur Navigaton springen . Mina R et al. Fatigue is independently associated with disease activity assessed using the Physician Global Assessment but not the SLEDAI in patients with systemic lupus erythematosus. , Subach RB , Shinada S , Arora S TOTAL DOCUMENTS. Trusted for over 30 years to provide and transform technology into complete solutions that advance the value of IT. Oxford Textbook of. AU - Morand, Eric. 2022 May;9(1):e000700. et al. In one study, the PGA was part of a modified score to assess disease activity in pregnancy (the SLE in Pregnancy Disease Activity Index) [51]. Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). The PGA was integrated in composite indices, including the definition of the LLDAS [12, 13, 29, 34, 37, 39, 40] and remission [29, 37] (Table1). In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. Introduction Physician global assessments of disease activity (medical doctor (MD) globals) are important outcomes. Thank you for submitting a comment on this article. 'Not at target': prevalence and consequences of inadequate disease control in systemic lupus erythematosus-a multinational observational cohort study. , Magder LS In most studies, the PGA was assessed by a rheumatologist experienced in SLE care or research and, as already stated, the ICC reliability was different for an untrained physician and a trained investigator [36]. Kiani AN The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. , Leung HW According to the authors, this difference was probably due to the greater familiarity of the physicians with the BILAG-2004 index. Lead Medical Director heading up the global collaboration with Pfizer for Enbrel trials. , Longenecker JC The measurements were in the form of a scale from 0 to 3 in 54 studies [2, 3, 9, 10, 12, 13, 21, 2469, 103], a 010 scale in 12 studies [4, 60, 7079], a 0100 scale in 9 studies [27, 40, 78, 8085], a 07 Likert scale [11, 78, 80], a 02 scale [53], a 04 scale [86] and a 05 scale [87]. et al. A good responsiveness for PGA was shown in eight studies. In 1988, Liang et al. watch for seizures after the procedure. For permissions, please email: journals.permissions@oup.com, This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (. , Ibaez D Direkt zum Inhalt springen . , Hochberg M. Touma Z , Gladman DD This suggests that the role of the PGA is limited for disease activity assessment when used as a single instrument. This study assesses the reliability of the PGA, measured by means of 0-100 mm visual analog scale (VAS), and the additional use of separate VAS scales for musculoskeletal (PhysMSK) and dermatologic (PhysSk) manifestations in patients with psoriatic arthritis (PsA). The PGA was developed on a 0 to 3 scale as part of the Lupus Activity Index. 2) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99], with the SLAM in 4 studies (r=0.470.65) [35, 76, 84, 99], with LAI in 2 studies (r=0.640.75) [68, 84], with BILAG in 2 studies (r=0.610.62) [35, 84] and with ECLAM in 2 studies (r=0.580.65) [35, 84]. Reviews and case series with fewer than five patients were excluded. The OMERACT defines an instrument as an outcome measure if it passes the three pillars of evidence: truth (that refers to validity), discrimination (that includes reliability and responsiveness) and feasibility. The PGA is intended to encapsulate the physician's judgement of overall disease activity.Consensus on whether the PGA should be performed prior to, or after the receipt of laboratory values is lacking. Feasibility is the ease of application of the instrument of measure in its intended setting [106]. Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. , Urowitz MB. In a post-hoc analysis of phase 3 belimumab trials, improvements and no worsening in the PGA were greater among SRI responders vs SRI non-responders (P<0.001) [52]. Unable to load your collection due to an error, Unable to load your delegates due to an error. Montreal, Canada Area. All rights reserved. LECTURE 10: MEDICAL SURGICAL NURSING. Measurement properties of the PGA were analysed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) terminology [19]. , Trendelenburg M Published by Oxford University Press on behalf of the British Society for Rheumatology. . AB - The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence . The SRI is a validated SLE disease activity instrument used to detect clinically meaningful improvement of disease in SLE clinical trials. The Physician's Global Assessment (PhGA) is a number without unit. The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. , Larson MG , Andreoli L , Koutsoviti S [80] considered worsening as any increase in the PGA from baseline; in the epratuzumab trial [87], a significant improvement was a 20% decrease in the PGA score evaluated after 12months of treatment. , Sadovici-Bobeica V According to the OMERACT, face validity is the degree to which the instrument appears to match with the target domain, according to experts [18]. Genetic linkage has related dysfunction of . , Sjwall C , Petri M. Furie RA Higher disease activity is an important predictor of both organ damage and mortality [2] and the attainment of low disease activity is associated with a reduction in early damage [5, 6]. The https:// ensures that you are connecting to the Unauthorized use of these marks is strictly prohibited. Supporting the face validity property, PGA was defined the gold standard in 11 studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88] and in 32 it was used as the reference to which other activity scores were compared, such as the SLEDAI [4, 10, 13, 25, 27, 28, 31, 33, 35, 36, 41, 46, 47, 50, 51, 53, 62, 65, 68, 72, 73, 76, 81, 9699], BILAG [4, 27, 35, 36, 46, 65, 72, 73, 81, 98], SLAM [4, 72, 76, 99], LAI [68, 88], patient global assessment [81, 83, 84] and ECLAM [35]. T1 - Associations between physicians' global assessment of disease activity and patient-reported outcomes in patients with systemic lupus erythematosus. , Dietzmann K , Roberts WN A validation study of the SRI for juvenile SLE [60] showed that exclusion of the BILAG or PGA from the SRI did not change the accuracy of the SRI in detecting improvement. Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. Funding: The study was funded through the training Bursary Programme 2019 of the SLEuro European Lupus Society. AU - Kasitanon, Nuntana. Rheumatology (Oxford). Schlencker A, Messer L, Ardizzone M, Blaison G, Hinschberger O, Dahan E, Sordet C, Walther J, Dory A, Gonzalez M, Kleinlogel S, Bramont-Nachman A, Barrand L, Payen-Revol I, Sibilia J, Martin T, Arnaud L. Lupus Sci Med. , Devilliers H , Oon S , Seaman AL Stojan G Objectives Remission in systemic lupus erythematosus (SLE) is defined through a combination of 'clinical SLE Disease Activity Index (cSLEDAI)=0', 'physician's global assessment (PGA) <0.5 . The PGA intraRR was assessed in three studies [10, 68, 94] and ranged from 0.55 [68] to 0.88 [10]. This potentially disfiguring disease can have significant impact on patient's quality of life (QoL) and is often refractory to many first- and second-line therapies. Thanks to this feature, the PGA was included in composite indices with the aim of rating manifestations not included in glossary-based instruments such as the SLEDAI and BILAG [3] or for which a threshold has been defined (cytopenia). , Garabajiu M 1 2. Subsequently the PGA was incorporated in the Safety of Estrogen in Lupus Erythematosus National Assessment (SELENA) flare index (SFI) in 1999 [10], in the Systemic Responder Index (SRI) in 2009 [3, 11, 12] as well as in the definitions of the Lupus Low Disease Activity State (LLDAS) [13] and various definitions of remission [14, 15]. 2021 Apr 8;5(1):33. doi: 10.1186/s41687-021-00298-x. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. The last EULAR/ACR recommendations recommended use of the PGA in the routine monitoring of SLE [16]. , Pilkington C Supervise the development of junior medical affairs staff . The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinicians judgement of overall SLE disease activity. et al. At least 1 issue from each virtual tour. , Kraag GR Construct validity is the degree to which the PGA relates to other instruments that measure the same concept [18]. , Clowse M. Moorthy LN , Kalunian K . No study has evaluated the correlation of PGA with damage measures. These results enabled its use as a gold standard for assessing flare and defining flare severity in several studies [21, 67, 88].