1 0 obj Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). JFIF ` ` ZExif MM * J Q Q Q C !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? Molecular Weight null. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Chemical Formula: (C6H10O5)n 1.4. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. lH5JWy}DgKRR"Fs "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. No. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge : 51395-75-6 Date Approved: 01/31/2008 Revision No. Microcrystalline Cellulose; Cellulose; Functions. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. << ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. Earth Supplied Products LLC. PDF (28.38 mb) 2022 Corporate Fact Sheet. . /Resources 2 0 R Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . 0.25 - 0.37. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. Cellulose microcrystalline. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. MSDS Ref. Microcrystalline Cellulose / Avicel PH-102. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. The figure below illustrates the structural organisation of cellulose within plants. CAS #: 9004-34-6 . Avicel PC 611 (FMC Biopolymer) Supplied by. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. q9;v80q>jZ Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. stream Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm >> Magazine: Material safety data sheet - FMC Corporation. ( Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. /MediaBox [0 0 612 792] Manufacturer: FMC BioPolymer. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. endobj <> Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. Revision No. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Date Approved: 05/25/2010. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. <> Molecular weight: Not Applicable 1.5. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. Explore how we work and why we apply science and creativity for a better world to everything we do. High performance lubricant that brings more to the tablet. Request media, explore upcoming events and read our latest updates. AVICEL RC 581. 1 0 obj In extrusion-spheronisation, it is the excipient of choice. MATERIAL SAFETY DATA SHEET. <> The data shown below apply only to Avicel PH 101. %PDF-1.3 The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Aqueous suspensions of microcrystalline cellulose have . Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . Instead, they obtained a stable colloidal suspension. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . P}MFbN#[>r(y Battista, O. pH 6.0 to 8.0 . Learn about FMC's differentiated biologically-based crop solutions. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. *r_ *?~4$ &0Y# J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P It is also used in plaque assays for counting. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. <> FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . endstream 130. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. SUBSTANCE IDENTIFICATION 1.1. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. stream By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Fiber supplements can lessen the absorption of some . 2021 Annual Report. Learn about FMC's industry leading goal of net-zero emissions by 2035. % pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. >> G2W4de=u183KGH{ vQ#4:1\wc Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . endobj cas:9000-11-7 msds Carboxymethyl cellulose. : 160182. However, if handling bulk powders, observance of appropriate safeguards is recommended. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. /Contents 4 0 R The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. We respect your privacy FMC Privacy Policy. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . INCI. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. X\o^ Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! common form is used in vitamin supplements or tablets. %PDF-1.4 Go to Investor Relations. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Watch Now. It is hygroscopic and insoluble in water. Thus, Avicel contributes no or very few calories to the food system. endobj The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Unique functionality for a broad range of pharmaceutical applications.
Mostar Bridge Jump Injuries, 5 Letter Words Containing A And U, How To Get To Garden Of Eden Santa Cruz, Fiche De Paie Mcdo En Ligne, Articles M