Caryophyllene Oxide vs Caryophyllene this typically happens during the curing process with cannabis, though it also appears in many dried spices like basil, black pepper, and oregano and is responsible for a spicy, warm, and funky aroma similar to cloves and cinnamon. Caryophyllene Terpene Review: What Is It And What It DoesCARYOPHYLLENE OXIDE (cas 1139-30-6) SDS(Safety Data Sheet ... In addition, caryophyllene oxide is the oxidation product of β-caryophyllene. Part I. Spectroscopic methods and chemical shift structure correlations in caryophyllene oxide Magnetic Resonance in Chemistry: 1998: Biotransformation of caryophyllene oxide by cultured cells of Eucalyptus perriniana Phytochemistry: 1994 This terpene may be added in multiple topical skin products, hair conditioners, shampoos, cooking sauces and detergents as well. It is found in many plants, fragerances, preservatives, additives, and flavoring agents. China Catalog of Hazardous chemicals 2015: Not Listed. Its antifungal activity has been compared to ciclopiroxolamine and sulconazole, commonly used in onychomycosis treatment and chosen … It has been used in cosmetics, drugs, food preservatives, and for training drug-sniffing dogs by law enforcement. (-)-Caryophyllene oxide (-)-Caryophyllene oxide: 1139-30-6: none: European Inventory of Existing Commercial Chemical Substances (EINECS) Listed. A-38, Phase 2nd, Sector 80, Noida - 201305, Dist. Caryophyllene-Oxide is the only terpene that can bind with the CB2 receptors in the human body, which makes it highly beneficial for medicinal use. Help. Myrtenal and β-caryophyllene oxide in PEL inhibited IL-1β and TNF-α production in RA-FLS. It is an "isomer" of BCP. Log Octanol-Water Partition Coef (SRC): Log Kow (KOWWIN v1.67 estimate) = 4.91 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42): Boiling Pt (deg C): 263.48 (Adapted Stein & Brown method) Melting Pt (deg C): 62.95 (Mean or Weighted MP) VP(mm Hg,25 deg C): 0.01 (Modified Grain method) MP . In Malayalam, it is known as Sivatulasi. 1).In this review, we will focus on two . It's an oxidation product of β-caryophyllene, which can occur during the harvest's cure. Caryophyllene comes in several forms (called isomers), most commonly β-caryophyllene (BCP), its oxide (BCPO), or α-humulene. The product contains following substances which are hazardous for the environment. It is known to be naturally present in several essential oils and has a role to play as a food flavoring agent. In English, it is known as Holy basil. Both BCP and BCPO are thought to have cancer-fighting properties, and so are the most . In addition, caryophyllene oxide has also been indicated as an anticoagulant with platelets ATTRIBUTES Sources Caryophyllene oxide at the doses of 12.5 and 25mg/kg body wt. * Refer to Certificate of Analysis for lot specific data (including water content). In addition, caryophyllene oxide has also been indicated as an anticoagulant with platelets. Laboratory Chemical Safety Summary (LCSS) Datasheet. day −1, against amastigotes, the parasite form present in the mammalian host and the one responsible for . Caryophyllene Oxide and lupenone have synergistic effect against Trypanosoma cruzi. β-Caryophyllene (BCP), a natural bicyclic sesquiterpene, is a selective phytocannabinoid agonist of type 2 receptors (CB2-R). Industry Leader TrustSEAL Verified Verified Exporter. Application: (−)-Caryophyllene oxide is a carefully purified sesquiterpene. Caryophyllene oxide. Caryophyllene oxide is present in plants' profiles like eucalyptus, lemon balm, oregano, wormwood, rosemary, guava, black pepper, and clove. C15H24O. The results also showed that β-caryophyllene oxide evidenced cytotoxicity in both a dose-dependent and time-dependent manner. For Research Use Only. Solid-state13C chemical shift tensors in terpenes. Caryophyllene is a potent component in anti-inflammatory salves and topicals and also has potential anticancer, antibacterial, antifungal, and antiseptic properties. Caryophyllene oxide, an oxygenated terpenoid, well known as preservative in food, drugs and cosmetics, has been tested in vitro as an antifungal against dermatophytes. Caryophyllene oxide: 3: 29: Other Names for Ocimum tenuiflorum . The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. FDA Mainterm (SATF): 1139-30-6 ; BETA-CARYOPHYLLENE OXIDE. In chewing gum, caryophyllene has always been used as a flavoring agent to optimize a citrusy or spicy flavor profile. Caryophyllene is a potent component in anti-inflammatory salves and topicals and also has potential anticancer, antibacterial, antifungal, and antiseptic properties. β-Caryophyllene oxide (Sigma, Deisenhofen, Germany), β-caryophyllene, and eugenol acetate (Roth, Karlsruhe, Germany) were dissolved in Krebs-Henseleit solution by means of Arlatone 285 (castor oil, ethoxylated, CAS-No. By comparison with rabbit metabolic pathway, one can suspect that BCP may undergo (-)-Caryophyllene oxide is a bicyclic sesquiterpene and a metabolite of β-caryophyllene that has been found in C. sativa and has anticancer properties. Caryophyllene Oxide ₹ 350/ Kilogram. Introduction. Its strong wooden odor and a dry, fresh aroma with a hint of sweet spiciness are widely used in cosmetics and aromatherapy products. It has a woody smell and is often used in perfumes and cosmetics. Not Intended for Diagnostic or Therapeutic Use. Caryophyllene oxide, an oxygenated terpenoid, well known as preservative in food, drugs and cosmetics, has been tested in vitro as an antifungal against dermatophytes. Attributes: Pain Relief , Anti-Inflammatory , Antifungal , Antioxidant 1). BETA-CARYOPHYLLENE OXIDE: Used for (Technical Effect) FLAVORING AGENT OR ADJUVANT: Document Number (21 CFR) 172.515. United States Toxic Substances Control Act (TSCA) Inventory: Listed. Caryophyllene, more formally known as beta or b caryophyllene, is an extremely common terpene found in cannabis that is known for its herbal spiciness with hints of wood. Also used in soaps and detergents. A particularly interesting, but little known fact, is that Caryophyllene oxide is the compound responsible for identification of cannabis by drug-sniffing dogs. Caryophyllene Oxide Caryophyllene oxide is widely used in industry as a flavour and fragrance compound and recently has been patented as antitumor agent. Among the various biological activities, BCP exerts anti-inflammatory action via inhibiting the main inflammatory mediators, such as inducible nitric oxide synthase (iNOS . Everyday uses of caryophyllene oxide Characterized by a non-toxic and non-sensitizing profile, this natural compound is an approved flavoring by the Food and Drug Administration (FDA). In fact, it's so abundant that caryophyllene oxide is what drug-sniffing dogs smell when they identify cannabis. We make use of only highly effective compounds for formulating this oxide. Purity: ≥99%. The results demonstrated that more than 90% of caryophyllene oxide already evaporated in the air before the mice are inserted, thus confirming that the sedative activity observed is due to the action of caryophyllene oxide. Overall, dry weight yields increased with the application of 80 kg N/ha relative to the 0 kg N/ha and with . Use this list to discover caryophyllene-dominant weed strains and their effects. Substances used. It induces calcium currents in HL-60 cells expressing CB 2 receptors but also does so in CB 2-deficient cells. View Mobile Number. It isn't psychogenic due to the absence of an affinity to cannabinoid receptor type 1 (CB1). The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. 61791-12-6; ICI Surfactants, Essen, Germany), which did not influence contraction force in the final concentrations used. Caryophyllene ≥92% as beta-Caryophyllene, Biobased 100%: Odor Description: Woody-spicy, dry and tenacious Used in spice blends and citrus flavors, especially in chewing gum. In Telugu, it is known as Thulasi Aakulu. Caryophyllene-Oxide Natural is a bicyclic sesquiterpene that can be found in a variety of essential oils - it is most commonly pulled from clove, cannabis sativa, rosemary, and hops. Synonyms. These results indicate that SWE is an efficient method for the extraction of caryophyllene oxide and caryophyllene with high physiological activity. It can be used as an anti-inflammatory, local anesthetic, and natural insect repellent. @article{osti_21344773, title = {Toxic effects of carvacrol, caryophyllene oxide, and ascaridole from essential oil of Chenopodium ambrosioides on mitochondria}, author = {Monzote, Lianet and Stamberg, Werner and Staniek, Katrin and Gille, Lars}, abstractNote = {Chenopodium ambrosioides have been used for centuries in the Americas as a popular remedy for parasitic diseases. Caryophyllene is commonly found in black pepper, cloves, and cinnamon. 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